Prilosec OTC’s active ingredient, 20 mg of delayed released omeprazole, works to fight heartburn differently from treatments like acid controllers/H2s or antacids. Prilosec OTC heartburn medicine stands out; unlike traditional antacids omeprazole blocks acid production providing powerful heartburn relief that antacids can't match. Shop Prilosec OTC Omeprazole 20mg Delayed-Release Acid Reducer for Frequent Heartburn Tablets at CVS Pharmacy and enjoy free shipping on all eligible orders. Prilosec OTC’s active ingredient, 20 mg of delayed released omeprazole, works to fight heartburn differently from treatments like acid controllers/H2s or antacids. What is Prilosec OTC? Prilosec OTC is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. This medicine is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Prilosec OTC is a proton pump inhibitor (PPI) specially designed to treat frequent heartburn, the omeprazole acid reducer tablets prevent excess acid production to keep your heartburn in check, working all day & all night to provide heartburn relief for a full 24 hours*. The FDA is announcing the approval of Prilosec OTC (omeprazole) as an over-the-counter (OTC) drug product. Until today, Prilosec was available only with a doctor’s prescription. The active ingredient in Prilosec OTC is omeprazole, which is a proton pump inhibitor (PPI), a class of drugs used to treat frequent heartburn symptoms by reducing the acid in the stomach that can cause heartburn. Take one pill a day with a glass of water before eating in the morning for 14 days. Prilosec OTC is a proton pump inhibitor (PPI) specially designed to treat frequent heartburn, the omeprazole acid reducer tablets prevent excess acid production to keep your heartburn in check, working all day & all night to provide heartburn relief for a full 24 hours*. Find patient medical information for Omeprazole (Prilosec, Prilosec OTC) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.