What is Prilosec OTC? Prilosec OTC is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. This medicine is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Find patient medical information for Omeprazole (Prilosec, Prilosec OTC) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Buy Prilosec OTC, Omeprazole 20mg, Omeprazole, Heartburn Medicine, 24 Hour Omeprazole Relief, 42 Tablets at Walmart.com. HSA/FSA eligible, making your health and wellness purchases more manageable Shop Prilosec OTC Omeprazole 20mg Delayed-Release Acid Reducer for Frequent Heartburn Tablets at CVS Pharmacy and enjoy free shipping on all eligible orders. Find lasting relief from frequent heartburn with Prilosec OTC. One daily pill blocks heartburn so you can enjoy meals and restful nights. Prilosec OTC is a proton pump inhibitor (PPI) specially designed to treat frequent heartburn, the omeprazole acid reducer tablets prevent excess acid production to keep your heartburn in check, working all day & all night to provide heartburn relief for a full 24 hours*. Buy Prilosec OTC, Omeprazole Delayed Release 20mg, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief, All Day, All Night*, Heartburn Medicine, 20mg, Wildberry Flavor, 42 Tablets on Amazon.com FREE SHIPPING on qualified orders Prilosec OTC is a proton pump inhibitor (PPI) specially designed to treat frequent heartburn, the omeprazole acid reducer tablets prevent excess acid production to keep your heartburn in check, working all day & all night to provide heartburn relief for a full 24 hours*. Omeprazole brand names are Prilosec, Prilosec OTC, and generic brands are available. Omeprazole is available over the counter (OTC) and as a prescription medication. Yes, Prilosec is available over the counter as Prilosec OTC, a 20-milligram (mg) omeprazole tablet. Omeprazole OTC is also available under several store-specific generics.